Journal
BIOORGANIC CHEMISTRY
Volume 101, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2020.103966
Keywords
Nitric oxide inhibitory effects; Ajuga pantantha; Diterpenoids; Inflammation; Molecular docking; Zebrafish model
Funding
- National Key Research and Development Program of China [2018YFA0507204]
- National Natural Science Foundation of China [U1703107, U1801288, 21665013]
- Hundred Young Academic Leaders Program of Nankai University
- Natural Science Foundation of Tianjin [19JCYBJC28100]
- State Key Laboratory of Drug Research [SIMM2004KF-13]
- open project of Key Laboratory of Xinjiang Uygur Autonomous Region [2015KL030, 2017D04019]
- Scientific Research Program of the Higher Education Institution of Xinjiang Uygur Autonomous Region [XJEDU20171010]
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A phytochemical survey to obtain bioactive natural products from Ajuga pantantha afforded five new neo-cler-odane diterpenoids (1-5). The structures were established by analysis of their NMR spectroscopic data, and electronic circular dichroism calculations were applied to define their absolute configurations. Compounds 2 and 5 were found to have the property of inhibiting NO production (IC50 values < 40 mu M). Molecular docking and Western blotting were used to study the mechanism of anti-inflammatory action. Furthermore, compound 5 with the highest activity was tested for its in vivo anti-inflammatory effects using a zebrafish model.
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