Journal
BIOORGANIC CHEMISTRY
Volume 98, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2020.103758
Keywords
Homotriterpenoid; Anti-inflammation; Zebrafish model; Molecular docking; Casearia kurzii
Funding
- National Key Research and Development Program of China [2018YFA0507204]
- National Natural Science Foundation of China [U1703107, U1801288, 21665013]
- Natural Science Foundation of Tianjin, China [19JCYBJC28100]
- Hundred Young Academic Leaders Program of Nankai University
- State Key Laboratory of Bioactive Substance and Function of Natural Medicines (Institute of Materia Medica, Chinese Academy of Medical Sciences) [GTZK201902]
- State Key Laboratory of Bioactive Substance and Function of Natural Medicines (Peking Union Medical College) [GTZK201902]
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Caseahomopene A (1), a rare natural product with a ring-expanded homotriterpenoid skeleton, was isolated from the leaves of Casearia kurzii. The structure including the absolute configuration was determined by spectroscopic data and X-ray crystallography analysis. Compound 1 showed anti-inflammatory effects in vitro and in vivo using LPS-stimulated cell and zebrafish model. As a potential anti-inflammatory agent, the anti-inflammatory mechanism of 1 was also investigated.
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