Journal
BIOORGANIC CHEMISTRY
Volume 98, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2020.103733
Keywords
Antiviral agent; Benzo[d]thiazole; Hsp90; Influenza virus
Funding
- Slovenian Research Agency [P1-0208, J1-1717, BI-US/18-19078]
- Academy of Finland [277001, 304697, 312503]
- Academy of Finland (AKA) [304697, 312503, 304697, 312503] Funding Source: Academy of Finland (AKA)
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Seasonal or pandemic influenza virus infections are a worldwide health problem requiring antiviral therapy. Since virus resistance to the established neuraminidase inhibitors and novel polymerase inhibitors is growing, new drug targets are needed. Heat shock protein 90 (Hsp90) is associated with several aspects of the influenza virus life cycle, and is considered a relevant host cell target. We report here on a series of benzo[d]thiazole and 4,5,6,7-tetrahydrobenzo [d]thiazole derivatives with robust and selective activities against influenza A (H1N1, H3N2) and influenza B viruses. Two compounds, 1 and 4, have low micromolar EC50 values and show high binding affinities for Hsp90, which suggests that inhibition of Hsp90 is the mechanism underlying their antiviral effects. These compounds represent suitable scaffolds for designing novel Hsp90 inhibitors with favourable activities against influenza virus.
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