4.7 Review

Cancer immunotherapy: Pros, cons and beyond

Journal

BIOMEDICINE & PHARMACOTHERAPY
Volume 124, Issue -, Pages -

Publisher

ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2020.109821

Keywords

Cancer immunotherapy; Immune checkpoint inhibitors; Tumor microenvironment; CAR-T; PD-1

Funding

  1. National Natural Science Foundation of China [81541153]
  2. Guangdong Provincial Science and Technology Department [2016A050503046, 2015A050502048, 2016B030309002]
  3. Public Service Platform of South China Sea for R&D Marine Biomedicine Resources [GDMUK201808]
  4. Southern Marine Science and Engineering Guangdong Laboratory Zhanjiang [ZJW-2019-07]
  5. Zhanjiang Science and Technology Plan [2017A06012]
  6. Group-type Special Supporting Project for Educational Talents in Universities [4SG19057G]

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Cancer immunotherapy is an innovative treatment for tumors today. In various experiments and clinical studies, it has been found that immunotherapy does have incomparable advantages over traditional anti-tumor therapy, which can prolong progression-free survival (PFS) and overall survival (OS). However, immunotherapy has obvious complexity and uncertainty. Immunotherapy may also cause severe adverse reactions due to an over-active immune system. More effective and fewer adverse reactions immunological checkpoints are still under further exploration. This review gives an overview of recent developments in immunotherapy and indicates a new direction of tumor treatment through analyzing the pros and cons of immunotherapy coupled with keeping a close watch on the development trend of the immunotherapy future.

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