Journal
BIOMARKERS IN MEDICINE
Volume 14, Issue 7, Pages 525-538Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/bmm-2019-0241
Keywords
chemoresistance; colorectal cancer; FOLFOX; HNF4A; hub gene; meta-analysis; microarray; omicc; rankprod; transcriptome
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Funding
- [FRGS/1/2017/SKK08/UKM/03/3]
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Background: Finding a new target or a new drug to overcome chemoresistance is difficult due to the heterogenous nature of cancer. Meta-analysis was performed to combine the analysis of different microarray studies to get a robust discovery. Materials & methods: Herein, we analyzed three microarray datasets on combination of folinic acid, fluorouracil, and oxaliplatin drugs (FOLFOX) resistance that fit our inclusion/exclusion criteria and performed a meta-analysis using the OmiCC system. Results: We identified several deregulated genes and we discovered HNF4A as a hub gene. We performed functional validation and observed that by targeting HNF4A, HCT116 cells were more sensitive toward both oxaliplatin and 5-fluorouracil significantly. Conclusion: Our findings show that HNF4A could be a potential target in overcoming FOLFOX chemoresistance in colorectal cancer.
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