Journal
BIOMARKERS IN MEDICINE
Volume 14, Issue 7, Pages 513-524Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/bmm-2019-0410
Keywords
aortic stenosis; aortic valve replacement; cardiac remodeling; LVH; osteopontin; outcome
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Funding
- St. Jude Medical Germany
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Aim: The aim of this study was to evaluate the prognostic value of osteopontin (OPN) as a marker for left ventricular (LV) hypertrophy and its reversibility after surgical aortic valve replacement (SAVR). Patients & methods: Echocardiographic data and OPN plasma levels of 149 consecutive patients undergoing SAVR were obtained preoperatively and 3 months postoperatively. OPN was measured by Quantikine Human OPN immunoassay. Results: There was a significant correlation between higher OPN plasma levels and lower LV-mass regression. In patients receiving SAVR combined with coronary artery bypass grafting, high OPN plasma levels were also an indicator for eccentric hypertrophy phenotype. Conclusion: OPN may be a useful indicator for LV hypertrophy phenotype and could have a prognostic value to estimate LV-mass regression after SAVR.
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