Journal
BIOMARKERS IN MEDICINE
Volume 14, Issue 6, Pages 421-432Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/bmm-2019-0357
Keywords
COX-2; gastric cancer; metastasis; mTOR; prognosis
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Funding
- National Natural Science Foundation of China [81773944]
- Young Medicine Focus Talent Foundation of Jiangsu Province [QNRC2016206]
- Postgraduate Research by Practice Innovation Program of Jiangsu Province [KYCX18 2382]
- Natural Science Foundation of Jiangsu Province [BK20191149]
- China Postdoctoral Science Foundation [2018M642346]
- Wuxi City Health Planning Commission project [MS201815]
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Aim: Gastric cancer (GC) is one of the most common malignant tumors in the world. It is important to find accurate and reliable biomarkers in order to decrease whole morbidity and mortality. Results: We examined the expression of COX-2 and mTOR on GC tissue microarrays by immunohistochemistry. Multi-variate COX regression analysis showed that the expression of COX-2 or mTOR was an independent factor in the prognosis of GC patients. In addition, COX-2 and mTOR had the potentially synergistic effect on predicting the prognosis of GC. Conclusion: The combined expression of COX-2 and mTOR could serve as efficient prognostic indicators and COX-2 could suppress GC metastasis via regulating mTOR.
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