4.7 Article

GDASC: a GPU parallel-based web server for detecting hidden batch factors

Journal

BIOINFORMATICS
Volume 36, Issue 14, Pages 4211-4213

Publisher

OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btaa427

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Funding

  1. National Natural Science Foundation of China [61973174, 31728013]

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The Summary: We developed GDASC, a web version of our former DASC algorithm implemented with GPU. It provides a user-friendly web interface for detecting batch factors. Based on the good performance of DASC algorithm, it is able to give the most accurate results. For two steps of DASC, data-adaptive shrinkage and semi-non-negative matrix factorization, we designed parallelization strategies facing convex clustering solution and decomposition process. It runs more than 50 times faster than the original version on the representative RNA sequencing quality control dataset. With its accuracy and high speed, this server will be a useful tool for batch effects analysis.

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