Journal
BIOESSAYS
Volume 42, Issue 5, Pages -Publisher
WILEY
DOI: 10.1002/bies.201900205
Keywords
chromatin; chromatin evolution; chromosome; histones; subtelomere; telomere
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Funding
- Agence Nationale de la Recherche (ANR) [ANR-15-CE12-0007] Funding Source: Agence Nationale de la Recherche (ANR)
- Agence Nationale de la Recherche [ANR-15-CE12-0007, ANR-11-LABEX-0044_DEEP, ANR-10-IDEX-0001-02 PSL] Funding Source: Medline
- Medical Research Council [MC_A658_5TY40] Funding Source: Medline
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Specificities associated with chromosomal linearity are not restricted to telomeres. Here, recent results obtained on fission and budding yeast are summarized and an attempt is made to define subtelomeres using chromatin features extending beyond the heterochromatin emanating from telomeres. Subtelomeres, the chromosome domains adjacent to telomeres, differ from the rest of the genome by their gene content, rapid evolution, and chromatin features that together contribute to organism adaptation. However, current definitions of subtelomeres are generally based on synteny and are largely gene-centered. Taking into consideration both the peculiar gene content and dynamics as well as the chromatin properties of those domains, it is discussed how chromatin features can contribute to subtelomeric properties and functions, and play a pivotal role in the emergence of subtelomeres.
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