Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1867, Issue 5, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.bbamcr.2020.118662
Keywords
MicroRNA; Autophagy; Mammalian autophagy regulation; Post-transcriptional control
Categories
Funding
- Scientific and Technological Research Council of Turkey (TUBITAK) [114Z982]
- Sabanci University
- EMBO Strategical Development and Installation Grant (EMBO-SDIG)
- Turkish Academy of Sciences (TUBA) GEBIP Award
- TGC Sedat Simavi Health Sciences Award
- Elginkan Foundation Technology Award
- IKU Prof. Dr. Onder Oztunali Science Award
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Autophagy is a cellular stress response mechanism activation of which leads to degradation of cellular components, including proteins as well as damaged organelles in lysosomes. Defects in autophagy mechanisms were associated with several pathologies (e.g. cancer, neurodegenerative diseases, and rare genetic diseases). Therefore, autophagy regulation is under strict control. Transcriptional and post-translational mechanisms that control autophagy in cells and organisms studied in detail. Recent studies introduced non-coding small RNAs, and especially microRNAs (miRNAs) in the post-translational orchestration of the autophagic activity. In this review article, we analyzed in detail the current status of autophagy-miRNA connections. Comprehensive documentation of miRNAs that were directly involved in autophagy regulation resulted in the emergence of common themes and concepts governing these complex and intricate interactions. Hence, a better and systematic understanding of these interactions reveals a central role for miRNAs in the regulation of autophagy.
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