Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Volume 1863, Issue 5, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.bbagrm.2020.194505
Keywords
mRNA decay; mRNA degradation; Ribonucleases; RNA structure; RNA modification; Ribonuclease modification
Categories
Funding
- Centre National de la Recherche Scientifique (CNRS)
- Universite de Paris
- Agence Nationale de la Recherche (BaRR, CoNoCo)
- Labex Dynamo program
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Messenger RNA processing and decay is a key mechanism to control gene expression at the post-transcriptional level in response to ever-changing environmental conditions. In this review chapter, we discuss the main ribonucleases involved in these processes in bacteria, with a particular but non-exclusive emphasis on the two best-studied paradigms of Gram-negative and Gram-positive bacteria, E. coli and B. subtilis, respectively. We provide examples of how the activity and specificity of these enzymes can be modulated at the protein level, by co-factor binding and by post-translational modifications, and how they can be influenced by specific properties of their mRNA substrates, such as 5' protective 'caps', nucleotide modifications, secondary structures and translation. This article is part of a Special Issue entitled: RNA and gene control in bacteria edited by Dr. M. Guillier and F. Repoila.
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