4.3 Article

Toxins and other chemical constituents from Prorocentrum lima

Journal

BIOCHEMICAL SYSTEMATICS AND ECOLOGY
Volume 89, Issue -, Pages -

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bse.2020.104015

Keywords

Okadaic acid; Prorocentrolide; Fucoxanthin derivatives; Prorocentrum lima

Funding

  1. Central Public-interest Scientific Institution Basal Research Fund, CAFS [2016GH11]
  2. 948 project - Ministry of Agriculture and Rural Affairs of China [2015Z18]
  3. Scientific Instrument and Chemical Reagents Project of Shanghai Science and Technology Committee [15142201600]

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The marine phytoplankton Prorocentrum lima is one of the toxic and harmful microalgae which can cause red tides. In chemical investigation on cultured strain P. lima PL11, seven compounds were isolated and identified by spectroscopic data, including three typical shellfish toxins okadaic acid (OA, 1), OA methyl ester (2), and prorocentrolide (3), three terpenoids (4-6), and one polyketide (7). Compounds 5 and 6 should be derived from carotenoid fucoxanthin. Compounds 4-7 were isolated from this genus of microalgae for the first time.

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