Journal
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
Volume 33, Issue 6, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.berh.2020.101495
Keywords
Ankylosing spondylitis; Spondyloarthritis; Reactive arthritis; Microbiota; HLA-B27; Animal models
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Funding
- ANR (GEMISA)
- Fondation Arthritis and Clarins Worldwide 2016
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A causal link between the wealth of microbes that populate our body surfaces, designated as microbiota, and inflammatory disorders, including ankylosing spondylitis and the related spondyloarthritis (SpA) has been suspected for decades. This specially concerns the gut microbiota that became only recently accessible to thorough description thanks to massive sequencing methods or metagenomics. Here, we review evidences supporting the existence of microbiota imbalance or dysbiosis in the context of SpA. We also discuss currently existing evidences for a causal relationship between such dysbiosis and disease development, as well as putative therapeutic implications. (C) 2020 Elsevier Ltd. All rights reserved.
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