Journal
AUTOIMMUNITY REVIEWS
Volume 19, Issue 7, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.autrev.2020.102573
Keywords
COVID-19; Cytokine storm; Inflammation; Ferritin
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The severe form of COVID-19 share several clinical and laboratory features with four entities gathered under the term hyperferritinemic syndromes and including macrophage activation syndrome (MAS), adult-onset Still's disease (AOSD), catastrophic anti-phospholipid syndrome (CAPS) and septic shock. COVID-19 systemic inflammatory reaction and hyperferritinemic syndromes are all characterized by high serum ferritin and a life-threatening hyper-inflammation sustained by a cytokines storm which eventually leads to multi-organ failure. In this review, we analyze the possible epidemiological and molecular mechanisms responsible for hyper-inflammation in patients with severe COVID-19 and we underline the similarities between this condition and hyperferritinemic syndromeswhich would allow considering severe COVID-19 as a fifth member of this spectrum of inflammatory conditions.
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