Journal
AUTOIMMUNITY REVIEWS
Volume 19, Issue 8, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.autrev.2020.102530
Keywords
Microbiota; Metabolites; Rheumatic diseases; Autoimmunity responses
Categories
Funding
- National Natural Science Foundation of China [81770101, 81403041]
- Outstanding interdisciplinary project of West China Hospital, Sichuan University [ZYJC18024]
- Deutsche Forschungsgemeinschaft (DFG) [FOR2886, SFB1181]
- Bundesministerium fur Bildung und Forschung (BMBF) (MASCARA project)
- Bundesministerium fur Bildung und Forschung (BMBF) (METARTHROS project)
- European Union (ERC Synergy grant) [810316]
- EU/EFPIA Innovative Medicines Initiative 2 Joint Undertaking RTCure grant [777357]
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As a gigantic community in the human body, the microbiota exerts pleiotropic roles in human health and disease ranging from digestion and absorption of nutrients from food, defense against infection of pathogens, to regulation of immune system development and immune homeostasis. Recent advances in omics studies and bioinformatics analyses have broadened our insights of the microbiota composition of the inner and other surfaces of the body and their interactions with the host. Apart from the direct contact of microbes at the mucosal barrier, metabolites produced or metabolized by the gut microbes can serve as important immune regulators or initiators in a wide variety of diseases, including gastrointestinal diseases, metabolic disorders and systemic rheumatic diseases. This review focuses on the most recent understanding of how the microbiota and metabolites shape rheumatic diseases. Studies that explore the mechanistic interplay between microbes, metabolites and the host could thereby provide clues for novel methods in the diagnosis, therapy, and prevention of rheumatic diseases.
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