Journal
ATHEROSCLEROSIS
Volume 303, Issue -, Pages 36-42Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2020.04.020
Keywords
Histone deacetylase; Epigenetics; Acetylation; Deacetylation; Cardiovascular disease; Vascular smooth muscle cell; Endothelial; Atherosclerosis
Funding
- National Heart, Lung, and Blood Institute [R01 HL089405, R01 HL115265]
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Cardiovascular diseases are the leading cause of deaths in the world. Endothelial dysfunction followed by in- flammation of the vessel wall leads to atherosclerotic lesion formation that causes ischemic heart and myocardial hypertrophy, which ultimately progress into cardiac dysfunction and failure. Histone deacetylases (HDACs) have been recognized to play crucial roles in cardiovascular disease, particularly in the epigenetic regulation of gene transcription in response to a variety of stresses. The unique nature of HDAC regulation includes that HDACs form a complex co -regulatory network with other transcription factors, deacetylate histones and non-histone proteins to facilitate the regulatory mechanism of the vascular system. The selective HDAC inhibitors are con- sidered as the most promising target in cardiovascular disease, especially for preventing cardiac hypertrophy. In this review, we discuss our present knowledge of the cellular and molecular basis of HDACs in mediating the biological function of vascular cells and related pharmacologic interventions in vascular disease.
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