Journal
ATHEROSCLEROSIS
Volume 304, Issue -, Pages 44-52Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2020.04.019
Keywords
Cardiorespiratory fitness; Cardiovascular risk factors; Atherosclerosis; Stress testing; METS
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Cardiorespiratory fitness (CRF) refers to the ability of the cardiopulmonary system to supply oxygen to skeletal muscles during exercise. Regular physical activity optimizes these systems by physiologic means that not only decrease cardiovascular risk factors but also independently affect mortality. Importantly, CRF is an integrative measure of the effects of its upstream risk factors including physical activity and genetics. In this review, we summarize the main methods that are frequently used to estimate CRF. We cite findings from the major studies on CRF, which demonstrate a beneficial effect on prevalent cardiovascular risk factor burden, subclinical atherosclerosis, and incident adverse outcomes including death, myocardial infarction, stroke, and cancer. We conclude by suggesting the incorporation of CRF into clinical decision-making given the prognostic information it provides.
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