Journal
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
Volume 68, Issue 2, Pages -Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00005-020-00578-2
Keywords
Type 1 diabetes; Immune cells; Pancreas; Bioprintig; CRISP; CAS9
Categories
Funding
- National Centre for Research and Development [STRATEGMED3/305813/2/NCBR/2017]
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Interactions between the immune system and the pancreas are pivotal in understanding how and why beta cells' damage causes problems with pancreas functioning. Pancreatic islets are crucial in maintaining glucose homeostasis in organs, tissue and cells. Autoimmune aggression towards pancreatic islets, mainly beta cells, leads to type 1 diabetes-one of the most prevalent autoimmune disease in the world, being a worldwide risk to health of many people. In this review, we highlight the role of immune cells and its influence in the development of autoimmunity in Langerhans islets. Moreover, we discuss the impact of the immunological factors on future understanding possible recurrence of autoimmunity on 3D-bioprinted bionic pancreas.
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