Journal
ARCHIVES OF MEDICAL RESEARCH
Volume 51, Issue 3, Pages 282-286Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.arcmed.2020.03.004
Keywords
SARS-CoV-2; SARS; MERS; Polyunsaturated fatty acids; Arachidonic acid; Prostaglandins; Lipoxin A4; Resolvins; Protectins and maresins; Inflammation
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SARS-CoV-2, SARS and MERS are all enveloped viruses that can cause acute respiratory syndrome. Arachidonic acid (AA) and other unsaturated fatty acids (especially eicosapentaenoic acd, EPA and docosahexaenoic acid DHA) are known to inactivate enveloped viruses and inhibit proliferation of various microbial organisms. The pro-inflammatory metabolites of AA and EPA such as prostaglandins, leukotrienes and thromboxanes induce inflammation whereas lipoxins, resolvins, protectins and maresins derived from AA, EPA and DHA not only suppress inflammation but also enhance would healing and augment phagocytosis of macrophages and other immunocytes and decrease microbial load. In view of these actions, it is suggested that AA and other unsaturated fatty acids and their metabolites may serve as endogenous anti-viral compounds and their deficiency may render humans susceptible to SARS-CoV-2, SARS and MERS and other similar viruses' infections. Hence, oral or intravenous administration of AA and other unsaturated fatty acids may aid in enhancing resistance and recovery from SARS-CoV-2, SARS and MERS infections. (C) 2020 IMSS. Published by Elsevier Inc.
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