The effect of dietary vitamin D3, minerals (Ca, P) and plant-protein sources in the development of systemic granulomatosis in meagre (Argyrosomus regius, Asso, 1801)

Systemic Granulomatosis (SG) affects the majority of cultured meagre (Argyrosomus regius). This pathological condition, whose aetiology is still not known, is identified by multiple granulomas in a variety of organs that become calcified and necrotic with time. The available evidence supports the hypothesis that SG is a metabolic disorder associated with nutritional imbalances, and the present study examined the role of dietary vitamin D-3, minerals (Ca, P) and plant-protein sources in the development of the disease. The use of plant-protein in the diet formulation exacerbated the progression of SG, while vitamin D-3 did not prevent its occurrence. On the other hand, the severity of SG was improved by increasing the P content in the feed. However, the exact irritant that causes this inflammatory response in meagre is still unknown and more research needs to examine other nutritional factors.