Journal
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Volume 104, Issue 10, Pages 4259-4272Publisher
SPRINGER
DOI: 10.1007/s00253-020-10537-8
Keywords
Saccharomyces cerevisiae; Bio-based production; Dicarboxylic acids; Metabolic pathway
Categories
Funding
- National Key R&D Program of China [2019YFA09005502]
- National Natural Science Foundation of China [21877053, 31601564]
- Natural Science Foundation of Jiangsu Province [BK20181345]
- National First-class Discipline Program of Light Industry Technology and Engineering [LITE2018-24]
- Open Project Program of China-Canada Joint Lab of Food Nutrition and Health, Beijing Technology and Business University
Ask authors/readers for more resources
Dicarboxylic acids are widely used in fine chemical and food industries as well as the monomer for polymerisation of high molecular material. Given the problems of environmental contamination and sustainable development faced by traditional production of dicarboxylic acids based on petrol, new approaches such as bio-based production of dicarboxylic acids drew more attentions. The yeast, Saccharomyces cerevisiae, was regarded as an ideal organism for bio-based production of dicarboxylic acids with high tolerance to acidic and hyperosmotic environments, robust growth using a broad range of substrates, great convenience for genetic manipulation, stable inheritance via sub-cultivation, and food compatibility. In this review, the production of major dicarboxylates via S. cerevisiae was concluded and the challenges and opportunities facing were discussed. Key Points center dot Summary of current production of major dicarboxylic acids by Saccharomyces cerevisiae. center dot Discussion of influence factors on four-carbon dicarboxylic acids production by Saccharomyces cerevisiae. center dot Outlook of potential production of five- and six-carbon dicarboxylic acids by Saccharomyces cerevisiae.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available