Journal
APPLIED BIOCHEMISTRY AND MICROBIOLOGY
Volume 56, Issue 3, Pages 313-320Publisher
PLEIADES PUBLISHING INC
DOI: 10.1134/S0003683820030163
Keywords
biotransformation; endophyte; Polygonum cuspidatum; Penicillium sp; F5; pterostilbene
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Funding
- National Key Research and Development Program of China [2017YFB0308401]
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In this study, fungal endophytes were screened from samples of Polygonum cuspidatum and 24 endophytes were obtained. The fungal endophytes were allocated to 6 orders and 9 genera by phylogenetic analysis. Based on the ability of fungal endophytes to induce biotransformation, Penicillium sp. F5 was selected for the biotransformation of resveratrol. Fermentation of media using Penicillium sp. F5 yielded transformation products, giving a main product that was purified using silica gel column chromatography. The structure of main product was established as pterostilbene (trans-3,5-dimethoxy-4'-hydroxystilbene) by using H-1-NMR, C-13 -NMR, HSQC and HMBC spectroscopy. Pterostilbene plays an important role in resisting disease in humans and shows more metabolic stability, stronger pharmacological activities, and longer half-life when compared with resveratrol.
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