Journal
CARDIOVASCULAR THERAPEUTICS
Volume 34, Issue 1, Pages 37-48Publisher
WILEY-HINDAWI
DOI: 10.1111/1755-5922.12166
Keywords
Cardiac disorders; Inflammation; Nonmetabolic; Nuclear receptors; Oxidative stress
Funding
- European Union (European Social Fund)
- Greek National Funds of the National Strategic Reference Framework (Programs Heracleitus II, Cooperation) [09SYN-21-965, GSRT-HUN57]
- [VEGA SR 2/0201/15]
- [APVV-0102-11]
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Peroxisome proliferator-activated receptors, PPAR, PPAR/, and PPAR, are a group of nuclear receptors that function as transcriptional regulators of lipid metabolism, energy homeostasis, and inflammation. Given the role of metabolism imbalance under pathological states of the heart, PPARs have emerged as important therapeutic targets, and accumulating evidence highlights their protective role in the improvement of cardiac function under diverse pathological settings. Although the role of PPARs in the regulation of cardiac substrate utilization preference and energy homeostasis is well documented, their effects related to the regulation of cellular inflammatory and redox responses in the heart are less studied. In this review, we provide an overview on recent progress with respect to understanding the role of the nonmetabolic effects of PPARs in cardiac dysfunction, namely during ischemia/reperfusion injury, hypertrophy, and cardiac failure, and highlight the mechanisms underlying the protective effects against inflammation, oxidative stress, and cell death. The role of receptor-independent, nongenomic effects of PPAR agonists is also discussed.
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