Journal
ANTICANCER RESEARCH
Volume 40, Issue 5, Pages 2989-2993Publisher
INT INST ANTICANCER RESEARCH
DOI: 10.21873/anticanres.14279
Keywords
Atypical endometrial hyperplasia; endometrial cancer; hysterectomy; magnetic resonance imaging; preoperative procedure
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Background/Aim: To evaluate the role of MRI in patients with atypical endometrial hyperplasia (AEH) and incorporate MRI findings in predictive models estimating the risk of co-existent endometrial cancer (EC). Patients and Methods: Data from 189 women diagnosed with AEH and had MRI scan prior to operation, over nine years, were retrospectively collected. Results: Histology showed EC in 51 (27%) cases. Presence of myometrial invasion on MRI was more commonly detected in patients with EC compared to those with benign pathology (37.3% versus 10.9%, p<0.001). The sensitivity and specificity of MRI in identifying cancer were 37% and 89%, respectively. Age, menopausal status and presence of invasion on MRI were the best predictors for the presence of malignancy. Conclusion: Myometrial invasion on MRI is associated with increased risk of EC in women with AEH. Its accuracy in detecting malignancy improves when combined with clinical parameters. This could be of value for conservative-management candidates.
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