Journal
ANNUAL REVIEW OF IMMUNOLOGY, VOL 38
Volume 38, Issue -, Pages 99-121Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-042617-053104
Keywords
B lymphocyte; heart failure; cardiac injury; vascular disease; adaptive immunity; innate immunity
Categories
Funding
- National Institutes of Health [R01 HL58081, HL-73017-0, HL089543-01, T32 HL007081]
- Center for Cardiovascular Research at Washington University School of Medicine
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B cells are traditionally known for their ability to produce antibodies in the context of adaptive immune responses. However, over the last decade B cells have been increasingly recognized as modulators of both adaptive and innate immune responses, as well as players in an important role in the pathogenesis of a variety of human diseases. Here, after briefly summarizing our current understanding of B cell biology, we present a systematic review of the literature from both animal models and human studies that highlight the important role that B lymphocytes play in cardiac and vascular disease. While many aspects of B cell biology in the vasculature and, to an even greater extent, in the heart remain unclear, B cells are emerging as key regulators of cardiovascular adaptation to injury.
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