Journal
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 89
Volume 89, Issue -, Pages 103-133Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-biochem-011520-104722
Keywords
checkpoint; DNA double-strand break; DNA repair; kinases; cell cycle
Categories
Funding
- National Institutes of Health (NIH) [R01GM61766, R35GM127029, R01GM097272, R01HD095296]
- NIH Genetics Training Grant [TM32 GM007122]
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Cells confront DNA damage in every cell cycle. Among the most deleterious types of DNA damage are DNA double-strand breaks (DSBs), which can cause cell lethality if unrepaired or cancers if improperly repaired. In response to DNA DSBs, cells activate a complex DNA damage checkpoint (DDC) response that arrests the cell cycle, reprograms gene expression, and mobilizes DNA repair factors to prevent the inheritance of unrepaired and broken chromosomes. Here we examine the DDC, induced by DNA DSBs, in the budding yeast model system and in mammals.
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