Journal
ANNALS OF BIOMEDICAL ENGINEERING
Volume 49, Issue 1, Pages 139-148Publisher
SPRINGER
DOI: 10.1007/s10439-020-02526-9
Keywords
Dean flow focusing; Inertial separation; Solvent casting
Categories
Funding
- NSF [ECCS1609074, CMMI1562468]
- Maryland NanoCenter and its FabLab
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A thermoplastic microfluidic substrate is integrated onto a conventional venipuncture syringe to form a spiral inertial separation element for isolating plasma from diluted whole blood. The system enables plasma separation without the need for external instrumentation, achieving a peak separation efficiency above 97% using 25x diluted blood through Dean flow focusing.
A thermoplastic microfluidic substrate is conformally integrated onto the cylindrical barrel of a conventional venipuncture syringe, forming a spiral inertial separation element supporting the isolation of plasma from diluted whole blood. The cylindrical shape of the syringe itself serves to define the flow path required for inertial separation by transforming a linear microchannel to a spiral topology. The hybrid system enables inertial plasma separation by Dean flow focusing within the same syringe used for a patient blood draw, with the seamlessly interconnected microfluidic element operated by automated or manual actuation of the syringe plunger. Plasma isolation is achieved without the need for external instrumentation. Device design and fabrication challenges are discussed, and effective plasma isolation within the system is demonstrated, with a peak separation efficiency above 97% using 25 x diluted blood.
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