Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 34, Pages 14584-14592Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202005624
Keywords
aptamers; drug delivery; gold nanoparticles; nucleic acids; self-assembly
Categories
Funding
- National Natural Science Foundation of China (NSFC) [21775024]
- Key Project of Natural Science Foundation of Fujian Province [2019J02005]
- Natural Sciences and Engineering Council of Canada Discovery Grant
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Herein, we report on the design of a programmable DNA ribbon using long-chain DNA molecules with a user-defined repetitive padlock sequence. The DNA ribbon can be further combined with gold nanoparticles (AuNPs) to create a composite nanomaterial that contains an AuNP core and a high-density DNA crown carrying a cancer-cell-targeting DNA aptamer, a fluorescent tag for location tracking, and a cell-killing drug. This composite material can be efficiently internalized by cancer cells and its cellular location can be tracked by fluorescence imaging. The system offers several attractive characteristics, including simple design, tunable DNA crown, high drug-loading capacity, selective cell targeting, and pH-sensitive drug release. These features make such a material a promising therapeutic agent.
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