Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 52, Pages 23374-23385Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202003545
Keywords
functional materials; mRNA delivery; nanotechnology; regulated translation; structure-function relationship
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Funding
- Australian Research Council
- Queensland Government
- Queensland node of the Australian National Fabrication Facility, Australian Microscopy and Microanalysis Research Facility at the Centre for Microscopy and Microanalysis
- University of Queensland
- Science and Technology Commission of Shanghai Municipality, China [19JC1412100]
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Introducing mRNA into cells has attracted intense interest for diverse applications; however, success requires delivery solutions. Engineered nanomaterials have been applied as mRNA nanocarriers; their functions are designed mainly as delivery vehicles, but rarely in regulation of the protein translation. Recently, progress in nanobiotechnology has shifted the design principle of mRNA nanocarriers from simple delivery tools to translation modulators. Here, we review the emerging concepts of nanomaterials regulating mRNA translation and recent progress in mRNA delivery. Designer nanomaterials providing integrated functions for specific mRNA applications are also reviewed to provide insights for the design of next-generation nanomaterials to revolutionize mRNA technology.
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