Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 35, Pages 15029-15037Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202005657
Keywords
enzymatic release; mature sperm selection; microflake synthesis; micromotor; sperm swarm transport
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Funding
- China Scholarship Council (CSC)
- Leibniz Program of the German Research Foundation [SCHM 1298/26-1]
- German Research Foundation [SPP 1726]
- European Research Council (ERC) under the European Union [835268, 853609]
- European Research Council (ERC) [835268, 853609] Funding Source: European Research Council (ERC)
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An integrated system combining a magnetically-driven micromotor and a synthetized protein-based hyaluronic acid (HA) microflake is presented for the in situ selection and transport of multiple motile sperm cells (ca. 50). The system appeals for targeted sperm delivery in the reproductive system to assist fertilization or to deliver drugs. The binding mechanism between the HA microflake and sperm relies on the interactions between HA and the corresponding sperm HA receptors. Once sperm are captured within the HA microflake, the assembly is trapped and transported by a magnetically-driven helical microcarrier. The trapping of the sperm-microflake occurs by a local vortex induced by the microcarrier during rotation-translation under a rotating magnetic field. After transport, the microflake is enzymatically hydrolyzed by local proteases, allowing sperm to escape and finally reach the target location. This cargo-delivery system represents a new concept to transport not only multiple motile sperm but also other actively moving biological cargoes.
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