Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 27, Pages 14779-14799Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201915718
Keywords
biosensors; chemical probes; dynamic nuclear polarization; hyperpolarization; NMR spectroscopy
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Funding
- Core Research for Evolutional Science and Technology (CREST) of Molecular Technology [JPMJCR13L4]
- Japan Science and Technology Agency
- KAKENHI [19H00919]
- Japan Society for the Promotion of Science
- Grants-in-Aid for Scientific Research [19H00919] Funding Source: KAKEN
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Nuclear hyperpolarization is a method to enhance the sensitivity of NMR spectroscopy, allowing for highly sensitive biomedical molecular imaging. Recent development of molecular probes for hyperpolarized in vivo analysis has shown the unique metabolic and physiological information that this technique can provide.
Nuclear hyperpolarization has emerged as a method to dramatically enhance the sensitivity of NMR spectroscopy. By application of this powerful tool, small molecules with stable isotopes have been used for highly sensitive biomedical molecular imaging. The recent development of molecular probes for hyperpolarized in vivo analysis has demonstrated the ability of this technique to provide unique metabolic and physiological information. This review presents a brief introduction of hyperpolarization technology, approaches to the rational design of molecular probes for hyperpolarized analysis, and examples of molecules that have met with success in vitro or in vivo.
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