Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 11, Pages 5644-5665Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202001876
Keywords
bioreductions; dehydrogenases; hydrogenation; reductases; reductive amination
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Funding
- European Research Commission (ERC) [648026]
- Netherlands Organisation for Scientific Research (VICI grant) [724.014.003]
- European Research Council (ERC) [648026] Funding Source: European Research Council (ERC)
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This review highlights the synthetic state-of-the-art and potential of enzymes catalyzing reductions, ranging from carbonyl, enone, and aromatic reductions to reductive aminations. Enzymes play a key role in producing chiral products with new functionalities, leading to alternative synthetic routes for high-added-value compounds and bulk chemicals.
Reductions play a key role in organic synthesis, producing chiral products with new functionalities. Enzymes can catalyse such reactions with exquisite stereo-, regio- and chemoselectivity, leading the way to alternative shorter classical synthetic routes towards not only high-added-value compounds but also bulk chemicals. In this review we describe the synthetic state-of-the-art and potential of enzymes that catalyse reductions, ranging from carbonyl, enone and aromatic reductions to reductive aminations.
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