Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 32, Pages 13238-13245Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202002180
Keywords
DNA nanotechnology; DNA structures; nonequilibrium processes; self-assembly; supramolecular chemistry
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Funding
- Associazione Italiana per la Ricerca sul Cancro, AIRC [21965]
- European Research Council, ERC [819160]
- European Research Council (ERC) [819160] Funding Source: European Research Council (ERC)
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Synthetic DNA has emerged as a powerful self-assembled material for the engineering of nanoscale supramolecular devices and materials. Recently dissipative self-assembly of DNA-based supramolecular structures has emerged as a novel approach providing access to a new class of kinetically controlled DNA materials with unprecedented life-like properties. So far, dissipative control has been achieved using DNA-recognizing enzymes as energy dissipating units. Although highly efficient, enzymes pose limits in terms of long-term stability and inhibition of enzyme activity by waste products. Herein, we provide the first example of kinetically controlled DNA nanostructures in which energy dissipation is achieved through a non-enzymatic chemical reaction. More specifically, inspired by redox signalling, we employ redox cycles of disulfide-bond formation/breakage to kinetically control the assembly and disassembly of tubular DNA nanostructures in a highly controllable and reversible fashion.
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