Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 36, Pages 15474-15479Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201916177
Keywords
DNA-polymer nanostructures; enzyme degassing; grafting-from approach; polymerization-induced self-assembly; RAFT polymerization
Categories
Funding
- European Union [319130]
- Deutsche Forschungsgemeinschaft [407426226, TRR 234]
- ERC [677960]
- Australian Research Council (ARC)
- Queensland University of Technology
- European Research Council (ERC) [677960] Funding Source: European Research Council (ERC)
Ask authors/readers for more resources
Nanostructures derived from amphiphilic DNA-polymer conjugates have emerged prominently due to their rich self-assembly behavior; however, their synthesis is traditionally challenging. Here, we report a novel platform technology towards DNA-polymer nanostructures of various shapes by leveraging polymerization-induced self-assembly (PISA) for polymerization from single-stranded DNA (ssDNA). A grafting from protocol for thermal RAFT polymerization from ssDNA under ambient conditions was developed and utilized for the synthesis of functional DNA-polymer conjugates and DNA-diblock conjugates derived from acrylates and acrylamides. Using this method, PISA was applied to manufacture isotropic and anisotropic DNA-polymer nanostructures by varying the chain length of the polymer block. The resulting nanostructures were further functionalized by hybridization with a dye-labelled complementary ssDNA, thus establishing PISA as a powerful route towards intrinsically functional DNA-polymer nanostructures.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available