Journal
ANDROLOGIA
Volume 53, Issue 1, Pages -Publisher
WILEY
DOI: 10.1111/and.13645
Keywords
bioinformatics; proteomics; seminal plasma; spermatozoa; varicocele
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Proteomics and bioinformatics analysis can reveal the molecular etiologies associated with poor semen quality in varicocele patients, particularly mitochondrial dysfunction. Through proteomic studies, potential reproductive biomarkers can be identified in varicocele patients, offering possibilities for the development of noninvasive diagnostic and therapeutic strategies.
Varicocele is one of the major causes of male infertility and has a negative impact on spermatogenesis. The conventional semen analysis does not reveal the underlying subcellular mechanisms associated with defects in spermatozoa. Proteomics and bioinformatics analysis can be used to identify the molecular aetiologies associated with poor semen quality in varicocele patients. Mitochondrial dysfunction has been identified as the main factor affecting normal physiological functions of spermatozoa. This article discusses the proteomic studies of spermatozoa and seminal plasma in varicocele patients. Proteomics can identify potential spermatozoa and seminal plasma biomarkers in varicocele-mediated male infertility. In future, these protein biomarkers can be useful in the development of noninvasive diagnostic and therapeutic strategies for varicocele patients.
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