Journal
CARDIOVASCULAR DIABETOLOGY
Volume 15, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/s12933-016-0439-9
Keywords
Cardiovascular disease; Chemokine; Chemokine CC motif ligand 4; Diabetes mellitus; Fifth CC chemokine receptor
Funding
- Taipei Veterans General Hospital [V101E1-013, V102C-155, V102E1-006, V103C-151]
- Taiwan's National Science Council [NSC 101-2314-B-010-058-MY3]
- UST-UCSD International Center of Excellence in Advanced Bio-engineering - Taiwan National Science Council I-RiCE Program [NSC-99-2911-I-009-101]
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Chemokines are critical components in pathology. The roles of chemokine CC motif ligand 4 (CCL4) and its receptor are associated with diabetes mellitus (DM) and atherosclerosis cardiovascular diseases. However, due to the complexity of these diseases, the specific effects of CCL4 remain unclear, although recent reports have suggested that multiple pathways are related to CCL4. In this review, we provide an overview of the role and potential mechanisms of CCL4 and one of its major receptors, fifth CC chemokine receptor (CCR5), in DM and cardiovascular diseases. CCL4-related mechanisms, including CCL4 and CCR5, might provide potential therapeutic targets in DM and/or atherosclerosis cardiovascular diseases.
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