Journal
ANALYTICAL CHEMISTRY
Volume 92, Issue 9, Pages 6401-6407Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.9b05499
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Funding
- JSPS KAKENHI [JP18H05398]
- Cooperative Research Program of Network Joint Research Center for Materials and Devices
- Iketani Science and Technology Foundation
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Accurate, simple, and valuable analytical methods for detection of food contamination are rapidly expanding to evaluate the validity of food product quality because of ethnic considerations and food safety. Herein molecularly imprinted nanogels (MIP-NGs), capable of porcine serum albumin (PSA) recognition, were prepared as artificial molecular recognition elements. The MIP-NGs were immobilized on a quartz crystal microbalance (QCM) sensor for detection of pork contamination in real beef extract samples. The MIP-NGs-based QCM sensor showed high affinity and excellent selectivity toward PSA compared to reference serum albumins from five different animals. The high PSA specificity of MIP-NGs led to the detection of pork contamination with a detection limit of 1% (v/v) in real beef extract samples. We believe the artificial molecular recognition materials prepared by molecular imprinting are a promising candidate for halal food control.
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