Journal
ANALYTICA CHIMICA ACTA
Volume 1104, Issue -, Pages 110-116Publisher
ELSEVIER
DOI: 10.1016/j.aca.2020.01.008
Keywords
Hydrazone chemistry; Toehold strand displacement cascade; 5-Hydroxymethylfurfural analysis
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Funding
- National Natural Science Foundation of China [31671923]
- Shanghai Pujiang Program [18PJD016]
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Hydrazone chemistry has been firstly explored as capturing mode for interface supported toehold strand displacement cascade (TSDC). The method has been further established for analysis of 5-hydroxymethylfurfural (HMF) based on hydrazone chemistry-mediated TSDC. HMF containing aldehyde group can be covalently captured by hydrazine group around magnetic bead through the formation of hydrazone bond, so as to inhibit the immobilization of hybrid duplex and the occurrence of TSDC. Thereby, HMF will cause the change of the fluorescence of modified magnetic bead. With simplicity, specificity, and sensitivity, the method has been successfully applied to analyze HMF in food samples. This paper gives a new insight to explore capturing mode for interface supported TSDC and the established method can be extended for analysis of saccharic derivatives. (C) 2020 Elsevier B.V. All rights reserved.
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