Journal
AMERICAN JOURNAL OF ROENTGENOLOGY
Volume 215, Issue 1, Pages 242-247Publisher
AMER ROENTGEN RAY SOC
DOI: 10.2214/AJR.19.22213
Keywords
cryotherapy; interventional radiology; percutaneous cryoablation; renal cell carcinoma
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OBJECTIVE. The purpose of this study was to evaluate the immediate and 3- and 5-year outcomes of patients with clinical stage T1 (cT1) biopsy-proven renal cell carcinoma (RCC) treated by image-guided percutaneous cryoablation at a regional interventional oncology center. MATERIALS AND METHODS. A prospectively maintained local interventional radiology database identified patients with cT1 RCC lesions that were treated by percutaneous cryoablation. Technical success, procedural complications (graded using the Clavien-Dindo classification system), and the residual unablated tumor rate were collated. Local tumor progression-free survival was estimated using Kaplan-Meier estimates. RESULTS. A total of 180 patients with 185 separate cT1 RCC lesions were identified. Mean patient age was 68.4 years (range, 341-88.9 years) and 52 patients (28.9%) were women. There were 168 (90.8%) and 17 (9.2%) cT1a and cT1b lesions, respectively, with a mean lesion size of 28.5 mm (range, 11-58 mm). Technical success was achieved in 183 of 185 (98.9%) patients. The major complication rate (Clavien-Dindo classification >= grade III) was 2.2% (four out of 185). Residual unablated tumor on the first follow-up scan was identified in four of 183 tumors (2.2%). Estimated local tumor progression-free survival at 3 and 5 years was 98.3% and 94.9%, respectively. No distant metastases or deaths attributable to RCC occurred. Mean estimated glomerular filtration rate (eGFR) before the procedure was 72.4 +/- 18.5 (SD) mL/min/1.73 m(2) and this was not statistically significantly different after the procedure (69.7 +/- 18.8 mL/min/1.73 m(2)), at 1 year (70.7 +/- 16.4 mL/min/1.73 m(2)), or at 2 years (69.8 +/- 18.9 mL/min/1.73 m(2) ) (p> 0.05). CONCLUSION. These data add to the accumulating evidence that image-guided cryoablation is an efficacious treatment for selected cT1 RCC with a low complication rate and robust 3- and 5-year outcomes.
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