Journal
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Volume 201, Issue 12, Pages 1488-1498Publisher
AMER THORACIC SOC
DOI: 10.1164/rccm.201906-1215OC
Keywords
aspirin-exacerbated respiratory disease; aspirin hypersensitivity; aspirin tolerance; leukotriene E-4; omalizumab
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Funding
- Practical Research Project for Allergic Diseases and Immunology, Japan Agency for Medical Research and Development [19ek0410040h0003]
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Rationale: Aspirin-exacerbated respiratory disease is characterized by severe asthma, nonsteroidal antiinflammatory drug hypersensitivity, nasal polyposis, and leukotriene overproduction. Systemic corticosteroid therapy does not completely suppress lifelong aspirin hypersensitivity. Omalizumab efficacy against aspirin-exacerbated respiratory disease has not been investigated in a randomized manner. Objectives: To evaluate omalizumab efficacy against aspirin hypersensitivity, leukotriene E-4 overproduction, and symptoms during an oral aspirin challenge in patients with aspirin-exacerbated respiratory disease using a randomized design. Methods: We performed a double-blind, randomized, crossover, placebo-controlled, single-center study at Sagamihara National Hospital between August 2015 and December 2016. Atopic patients (20-79 yr old) with aspirin-exacerbated respiratory disease diagnosed by systemic aspirin challenge were randomized (1:1) to a 3-month treatment with omalizumab or placebo, followed by a > 18-week washout period (crossover design). The primary endpoint was the difference in area under logarithm level of urinary leukotriene E-4 concentration versus time curve in the intent-to-treat population during an oral aspirin challenge. Measurements and Main Results: Sixteen patients completed the study and were included in the analysis. The area under the logarithm level of urinary leukotriene E-4 concentration versus time curve during an oral aspirin challenge was significantly lower in the omalizumab phase (median [interquartile range], 51.1 [44.5-59.8]) than in the placebo phase (80.8 [interquartile range, 65.4-87.8]) (P< 0.001). Ten of 16 patients (62.5%) developed oral aspirin tolerance up to cumulative doses of930 mg in the omalizumab phase (P< 0.001). Conclusions: Omalizumab treatment inhibited urinary leukotriene E-4 overproduction and upper/lower respiratory tract symptoms during an oral aspirin challenge, resulting in aspirin tolerance in 62.5% of the patients with aspirin-exacerbated respiratory disease.
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