Journal
AGE AND AGEING
Volume 49, Issue 6, Pages 974-981Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ageing/afaa054
Keywords
older people; education; deprivation; frailty; aged 80 and over; multi-morbidity
Categories
Funding
- Medical Research Council [G0500997, G0601333, MR/J50001X/1]
- Biotechnology and Biological Sciences Research Council
- Dunhill Medical Trust [R124/0509]
- National Institute of Health Research School for Primary Care [NIHR SPCR 303]
- NIHR Senior Investigator award
- British Heart Foundation [PG/08/026/24712]
- Unilever Corporate Research [CH-2008-1200]
- NewcastleUniversity
- Newcastle Healthcare Charity [CM/GW 25/9/06]
- North of England Commissioning Support Unit
- Medical Research Council [G0500997, MR/J50001X/1] Funding Source: researchfish
- MRC [G0601333, MR/J50001X/1, G0500997] Funding Source: UKRI
Ask authors/readers for more resources
Background: Using Newcastle 85+ Study data, we investigated transitions between frailty states from age 85 to 90 years and whether multi-morbidities and socioeconomic status (SES) modify transitions. Methods: The Newcastle 85+ Study is a prospective, longitudinal cohort study of all people born in 1921 in Newcastle and North Tyneside. Data included: a multidimensional health assessment; general practice record review (GPRR) and date of death. Using the Fried phenotype (participants defined as robust, pre-frail or frail), frailty was measured at baseline, 18, 36 and 60 months. Results: Frailty scores were available for 82% (696/845) of participants at baseline. The prevalence of frailty was higher in women (29.7%, 123/414) than men (17.7%, 50/282) at baseline and all subsequent time points. Of those robust at baseline, 44.6% (50/112) remained robust at 18 months and 28% (14/50) at age 90. Most (52%) remained in the same state across consecutive interviews; only 6% of the transitions were recovery (from pre-frail to robust or frail to pre-frail), and none were from frail to robust. Four or more diseases inferred a greater likelihood of progression from robust to pre-frail even after adjustment for SES. SES did not influence the likelihood of moving from one frailty state to another. Conclusions: Almost half the time between age 85 and 90, on average, was spent in a pre-frail state; multi-morbidity increased the chance of progression from robust and to frail; greater clinical intervention at the onset of a first chronic illness, to prevent transition to multi-morbidity, should be encouraged.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available