Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 362, Issue 13, Pages 2637-2641Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202000306
Keywords
C(sp(3))-H Arylation; Secondary C-H Activation; 2-Alkylpyridine; Aryl Iodide; Palladium
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Funding
- 64th China Postdoctoral Science Foundation [2018M641642]
- JSPS KAKENHI [JP 17H03016, 18H04656]
- Grants-in-Aid for Scientific Research [18H04656] Funding Source: KAKEN
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A pyridyl group-assisted palladium-catalyzed secondary C(sp(3))-H arylation protocol was developed. A substituent at the 3-position of the pyridyl group is proved to be important for promoting C-H arylation and controlling the regioselectivity. Aryl iodides can be used as coupling partners. The reaction proceeded in good to excellent yields with good functional group tolerance, even on the gram-scale. The preliminary asymmetric reaction was investigated using an L-proline derivative as a chiral ligand.
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