Journal
ADVANCED MATERIALS
Volume 32, Issue 17, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202000964
Keywords
engineered proteins; nanoparticles; NIR fluorescent imaging; tumor therapy
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Funding
- Chinese Academy of Sciences [ZDKYYQ20180001] Funding Source: Medline
- National Natural Science Foundation of China [21834007, 21877104, 21704099] Funding Source: Medline
- National Key Research and Development Program of China [2018YFA0902600] Funding Source: Medline
- Jilin Province Science Fund for Excellent Young Scholars [20190103072JH] Funding Source: Medline
- K. C. Wong Education Foundation [GJTD-2018-09] Funding Source: Medline
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Fluorescent proteins are investigated extensively as markers for the imaging of cells and tissues that are treated by gene transfection. However, limited transfection efficiency and lack of targeting restrict the clinical application of this method rooted in the challenging development of robust fluorescent proteins for in vivo bioimaging. To address this, a new type of near-infrared (NIR) fluorescent protein assemblies manufactured by genetic engineering is presented. Due to the formation of well-defined nanoparticles and spectral operation within the phototherapeutic window, the NIR protein aggregates allow stable and specific tumor imaging via simple exogenous injection. Importantly, in vivo tumor metastases are tracked and this overcomes the limitations of in vivo imaging that can only be implemented relying on the gene transfection of fluorescent proteins. Concomitantly, the efficient loading of hydrophobic drugs into the protein nanoparticles is demonstrated facilitating the therapy of tumors in a mouse model. It is believed that these theranostic NIR fluorescent protein assemblies, hence, show great potential for the in vivo detection and therapy of cancer.
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