Recent Progress on Cellulose-Based Ionic Compounds for Biomaterials

Glycans play important roles in all major kingdoms of organisms, such as archea, bacteria, fungi, plants, and animals. Cellulose, the most abundant polysaccharide on the Earth, plays a predominant role for mechanical stability in plants, and finds a plethora of applications by humans. Beyond traditional use, biomedical application of cellulose becomes feasible with advances of soluble cellulose derivatives with diverse functional moieties along the backbone and modified nanocellulose with versatile functional groups on the surface due to the native features of cellulose as both cellulose chains and supramolecular ordered domains as extractable nanocellulose. With the focus on ionic cellulose-based compounds involving both these groups primarily for biomedical applications, a brief introduction about glycoscience and especially native biologically active glycosaminoglycans with specific biomedical application areas on humans is given, which inspires further development of bioactive compounds from glycans. Then, both polymeric cellulose derivatives and nanocellulose-based compounds synthesized as versatile biomaterials for a large variety of biomedical applications, such as for wound dressings, controlled release, encapsulation of cells and enzymes, and tissue engineering, are separately described, regarding the diverse routes of synthesis and the established and suggested applications for these highly interesting materials.

Automated summary

Glycans play crucial roles in various organisms, with cellulose being the most abundant polysaccharide on Earth, predominantly providing mechanical stability in plants and finding wide applications. Advanced soluble cellulose derivatives and modified nanocellulose with diverse functional groups have made biomedical applications of cellulose feasible. Further development of bioactive compounds from glycans is inspired by native glycosaminoglycans and versatile biomaterials synthesized from cellulose derivatives and nanocellulose for diverse biomedical applications.