Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 154, Issue -, Pages 245-273Publisher
ELSEVIER
DOI: 10.1016/j.addr.2020.05.006
Keywords
Chinese herbal medicines; Liposomes; Anti-tumor effect; Targeting strategies; Tumor microenvironment
Categories
Funding
- NIH [CA198999]
- National Natural Science Foundation of China [81760639, 81603054]
- Fund of Health and Family Planning Commission of Jiangxi Province [2016A008]
- Natural Science Fund of Jiangxi Province [20171BAB215066]
- Foundation of Jiangxi Provincial Education Department [GJJ190666, GJJ190663]
- Young Jinggang Scholar of Jiangxi Province
- Jiangxi University of Traditional Chinese Medicine 1050 Youth Talent Project
- New Century Talents Project of Jiangxi Province [2017082]
- Fund for First-Rate Discipline of Chinese Materia Medica [JXSYLXK-ZHYAO055, JXSYLXK-ZHYAO056, JXSYLXK-ZHYAO019]
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Various bioactive ingredients have been extracted from Chinese herbal medicines (CHMs) that affect tumor progression and metastasis. To further understand the mechanisms of CHMs in cancer therapy, this article summarizes the effects of five categories of CHMs and their active ingredients on tumor cells and the tumor microenvironment. Despite their treatment potential, the undesirable physicochemical properties (poor permeability, instability, high hydrophilicity or hydrophobicity, toxicity) and unwanted pharmacokinetic profiles (short half-life in blood and low bioavailability) restrict clinical studies of CHMs. Therefore, development of liposomes through relevant surface modifying techniques to achieve targeted CHM delivery for cancer cells, i.e., extracellular and intracellular targets and targets in tumor microenvironment or vasculature, have been reviewed. Current challenges of liposomal targeting of these phytoconstituents and future perspective of CHM applications are discussed to provide an informative reference for interested readers. (C) 2020 Elsevier B.V. All rights reserved.
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