Research progress on the protective effects of licorice-derived 18β-glycyrrhetinic acid against liver injury

The first description of the medical use of licorice appeared in Shennong Bencao Jing, one of the well-known Chinese herbal medicine classic books dated back to 220-280 AD. As one of the most commonly prescribed Chinese herbal medicine, licorice is known as Guo Lao, meaning a national treasure in China. Modern pharmacological investigations have confirmed that licorice possesses a number of biological activities, such as antioxidation, anti-inflammatory, antiviral, immune regulation, and liver protection. 18 beta-glycyrrhetinic acid is one of the most extensively studied active integrants of licorice. Here, we provide an overview of the protective effects of 18 beta-glycyrrhetinic acid against various acute and chronic liver diseases observed in experimental models, and summarize its pharmacological effects and potential toxic/side effects at higher doses. We also make additional comments on the important areas that may warrant further research to support appropriate clinical applications of 18 beta-glycyrrhetinic acid and avoid potential risks.

Automated summary

Licorice, commonly prescribed in Chinese herbal medicine, has been utilized for centuries and is known as a national treasure in China. Its active component, 18 beta-glycyrrhetinic acid, has been extensively studied for its antioxidation, anti-inflammatory, antiviral, immune regulation, and liver protection properties, offering potential benefits for liver diseases and other health conditions.