Journal
ACS NANO
Volume 14, Issue 4, Pages 4509-4522Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.9b10195
Keywords
polymeric nanoparticles; lipophilicity; zeta-potential; protein corona; endothelial uptake; in vivo circulation
Categories
Funding
- Singapore NRF Competitive Research Program [R279-000-483-281]
- NRF Investigatorship [R279-000-444281]
- National University of Singapore [R279-000-482133]
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Polymeric nanoparticles play important roles in the delivery of a multitude of therapeutic and imaging contrast agents. Although these nanomaterials have shown tremendous potential in disease diagnosis and therapy, there have been many reports on the failure of these nanoparticles in realizing their intended objectives due to an individual or a combination of factors, which have collectively challenged the merit of nanomedicine for disease theranostics. Herein, we investigate the interactions of polymeric nanoparticles with biological entities from molecular to organism levels. Specifically, the protein corona formation, in vitro endothelial uptake, and in vivo circulation time of these nanoparticles are systematically probed. We identify the crucial role of nano carrier lipophilicity, zeta-potential, and size in controlling the interactions between nanoparticles and biological systems and propose a two-step framework in formulating a single nanoparticle system to regulate multiple biological effects. This study provides insight into the rational design and optimization of the performance of polymeric nanoparticles to advance their theranostic and nanomedicine applications.
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