Journal
ACS NANO
Volume 14, Issue 4, Pages 4523-4535Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.0c00007
Keywords
iontophoresis; electroconductive hydrogel; reverse electrodialysis; nanocarriers; transdermal drug delivery system
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Funding
- Ministry of Science, ICT and Future Planning by the Korean Government [NRF2016R1E1A1A01943393, NRF-2017M3A9C6031786]
- Ministry of SMEs and Startups by the Korean Government [S2609617]
- BioSensor Laboratories Inc.
- Korea Technology & Information Promotion Agency for SMEs (TIPA) [S2609617] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [IBS-R006-D1-2020-A00] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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We herein developed an iontophoretic transdermal drug delivery system for the effective delivery of electrically mobile drug nanocarriers (DNs). Our system consists of a portable and disposable reverse electrodialysis (RED) battery that generates electric power for iontophoresis through the ionic exchange. In addition, in order to provide a drug reservoir to the RED-driven iontophoretic system, an electroconductive hydrogel composed of polypyrrole-incorporated poly(vinyl alcohol) (PYP) was used. The PYP hydrogel facilitated electron transfer from the RED battery and accelerated the mobility of electrically mobile DNs released from the PYP hydrogel. In this study, we showed that fluconazole- or rosiglitazone-loaded DNs could be functionalized with charge-inducing agents, and DNs with charge modification resulted in facilitated transdermal transport via repulsive RED-driven iontophoresis. In addition, topical application and RED-driven iontophoresis of rosiglitazone-loaded DNs resulted in an effective antiobese condition displaying decreased bodyweight, reduced glucose level, and increased conversion of white adipose tissues to brown adipose tissues in vivo. Consequently, we highlight that this transdermal drug delivery platform would be extensively utilized for delivering diverse therapeutic agents in a noninvasive way.
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