Journal
ACS NANO
Volume 14, Issue 4, Pages 4007-4013Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.9b08166
Keywords
catalytic hairpin assembly; dynamic control; four-legged DNA walker; microparticle; pH-responsive triplex DNA
Categories
Funding
- Welch Foundation [F-1654]
- John Templeton Foundation [54466]
- National Research Foundation of Korea (NRF) - Korea government (MSIT) [2018R1C1B6001112]
- Korea University
- China Scholarship Council [201606340025]
- Fundamental Research Funds for the Central Universities [WK2060200026]
- China Postdoctoral Science Foundation [2018M630708]
- National Postdoctoral Program for Innovative Talents [BX20180285]
- National Research Foundation of Korea [21A20132112574, 2018R1C1B6001112] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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We have now constructed a four-legged DNA walker based on toehold exchange reactions whose movement is controlled by alternating pH changes. A well-characterized, pH-responsive CG-C+ triplex DNA was embedded into a tetrameric catalytic hairpin assembly (CHA) walker. The proton-controlled walker could autonomously move on otherwise unprogrammed micro-particles surface, and the walking rate and steps of walking were efficiently controlled by pH. The starting and stopping of the walker, and its association and dissociation from the micro-particles, could also be dynamically controlled by pH. The simple, programmable, and robust nature of this proton-controlled walker now provides the impetus for the development of a wide variety of more practical nanomachines.
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