Journal
ACS NANO
Volume 14, Issue 6, Pages 7170-7180Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.0c02110
Keywords
biomimetic materials; laminin; morphology transformation; peptide; nanoparticles
Categories
Funding
- National Natural Science Foundation of China [51890891, 51890894, 51725302, 21807020, 51573031, 11621505, 51573032]
- Strategic Priority Research Program of Chinese Academy of Sciences [XDB36000000]
- National Key R&D Program of China [2018YFE0205400]
- CAS Interdisciplinary Innovation Team
Ask authors/readers for more resources
Cancer therapeutic strategies based on angiogenesis attract great attention from fundamental and clinical research. Blocking oxygen and nutrition supply to tumor cells could inhibit the growth of tumors based on occlusion of blood vessels in the tumor. Herein, we report a dual-responsive peptide-based nanoparticle, mimicking the laminin fibrillogenesis specifically and highly efficiently in tumor vessels, resulting in the blockage of tumor vessels and the growth inhibition of tumors. The laminin mimic peptide (LMMP) is designed with a fibrillation sequence, a pH-responsive sequence, and a targeting sequence. The LMMP in nanoformulations is delivered to blood vessels in the tumors, where the microenvironment (pH and microthrombus) enable LMMP to process laminin fibrillogenesis, constructing fibrous networks. The laminin-like fibrous networks capture red blood cells etc., forming occlusion specifically in the tumor blood vessels to inhibit the growth of the tumor.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available